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SUMMARY:Inaugural Professorial Lecture: Ben Langmead
DESCRIPTION:Join Dean Schlesinger and the Whiting School community at the Don P. Giddens Inaugural Professorial Lecture  recognizing Ben Langmead as a professor in the Department of Computer Science. Please note the new start time of 5 p.m. \n“Moving From Strength to Strength: Full-Text Indexes for Pangenomes”\nWhen Ben Langmead began graduate school\, new DNA sequencers were producing data so rapidly that sequence alignment algorithms could not keep up. His work drew on the Burrows–Wheeler Transform (BWT) to build genome “indexes” small enough to fit in memory yet fast enough to keep pace. Since then\, the BWT has become the foundation for numerous sequence analysis methods. \nToday\, genomics is entering a new era. Instead of relying on a single human reference genome\, we now have hundreds—and soon thousands—of high-quality human genomes. Used effectively\, these “pangenomes” can improve analyses by reducing reference bias: the tendency of alignment algorithms to give inaccurate results in regions that differ from the reference. \nTo fully realize these benefits\, we must move beyond single-reference approaches and develop methods that consider many genomes at once. Fortunately\, the BWT is the perfect basis for making this next step. This talk will explain what the BWT is\, why it has been effective for DNA sequencing data\, and how Langmead’s group is extending BWT-based methods to index and analyze ever-larger pangenomes. \nAbout Ben Langmead\n\nBen Langmead is a professor of computer science at the Johns Hopkins University. His group develops methods and software to make high-throughput biological data easy for biomedical researchers to use\, drawing on ideas from sequence alignment\, text indexing\, and high-performance computing. He has released high-impact tools for sequencing data analysis\, including Bowtie and Bowtie 2. His paper describing Bowtie received the Genome Biology Award for Outstanding Paper in 2009\, and methods from his group have been cited more than 100\,000 times according to Google Scholar. \nNamed after the fifth dean of the Whiting School of Engineering\, the Don P. Giddens Inaugural Professorial Lecture Series was established in 1993 to honor newly promoted full professors and teaching professors.
URL:https://www.cs.jhu.edu/event/inaugural-professorial-lecture-ben-langmead/
LOCATION:Rose Auditorium\, Maxine F. Singer Building\, Carnegie Institute
CATEGORIES:Seminars and Lectures
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